孙坚

孙坚

 学科:基础兽医学        
电话/传真:15820215217          
电子邮件:jiansun@scau.edu.cn
通讯地址:广州市天河区五山路483号百家家乐唯一入口 510642        
教研室:药理教研室

个人简介

    孙坚,男,19846月出生于湖南省邵阳市,农业博士,青年教授,博士生导师,国际食品法典委员会(CAC)抗菌素耐药性中国专家组成员,中国畜牧兽医学会兽医药理学和毒理学分会理事,美国微生物学会会员,教育部“青年长江学者”,霍英东教育基金获得者,广东省“青年珠江学者”和广州市“珠江科技新星”。长期从事动物源细菌耐药性研究,旨在通过对动物源细菌的耐药性检测、耐药机制及传播方式的研究为解决日益严重的耐药现状提供理论依据,同时开发高通量平台筛选有效的抗生素佐剂,进一步为克服耐药菌提供有效的防控策略。近年来主持国家自然科学基金和十三五重点研发计划子课题等科研项目4项。在Nature Microbiology Nature CommunicationmBio等权威期刊发表SCI论文80余篇,其中第一或者通讯作者52篇。申请专利15项,授权5项,获软件著作权6项。

 学习经历:

    2007/92012/6,百家家乐唯一入口,基础兽医学,博士,导师:刘雅红

    2003/92007/6,广西大学,动物医学,学士,导师:吴文德

 工作经历:

    2016/12-至今, 百家家乐唯一入口,兽医学院,青年教授

    2015/10-至今,百家家乐唯一入口,兽医学院,副教授

    2013/10-2015/9,百家家乐唯一入口,兽医学院,讲师

    2012/7-2013/7,美国爱荷华州立大学,博士后,合作导师:张启敬

研究领域:

    动物源细菌耐药性的监测;耐药及传播机制研究;耐药性防控技术

 

承担科研项目情况:

1)国家自然科学基金面上项目,31972735,去甲肾上腺素激活SOS信号通路促进多重耐药质粒转移的机制研究,2020/01-2023/12,59万,在研,主持

2)国家自然科学基金青年科学基金项目,31402247,动物源大肠杆菌HI2型多重耐药质粒流行特征及亚抑菌浓度抗生素对其传播的影响,2015/01-2017/1225万元,已结题,主持

3)科技部十三五”国家重点研发计划,2016YFD0501301,畜禽重要病原耐药性检测与控制技术研究子课题,2016.01-2020.1268万,在研,主持

4)国家自然科学基金项目,31520103918,质粒协助沙门菌的适应性及其机制研究,2016/01-2020/12255万元,在研,参加

代表论著:(*通讯作者)(文献编写格式如下)

  1. Sun, J.#, Liao, X. P.#, D'Souza, A. W.#, Boolchandani, M.#, Li, S. H. #, Cheng, K., Luis Martinez, J., Li, L., Feng, Y. J., Fang, L. X., Huang, T., Xia, J., Yu, Y., Zhou, Y. F., Sun, Y. X., Deng, X. B., Zeng, Z. L., Jiang, H. X., Fang, B. H., Tang, Y. Z., Lian, X. L., Zhang, R. M., Fang, Z. W., Yan, Q. L., Dantas, G*. and Liu, Y. H.*,Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms. Nat Commun. 2020;11:1427.

  2. Wang, X., Xiong, E., Tian, T., Cheng, M., Lin, W., Wang, H., Zhang, G., Sun, J.*, Zhou, X.*, Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Lateral Flow Nucleic Acid Assay. ACS Nano. 2020; 14, 2497-2508.

  3. Cui, Z.H., Ni, W.N., Tang, T., He, B., Zhong, Z.X., Fang, L.X., Chen, L., Chen, C., Cui, C.Y., Liu, Y.H., Liao, X.P., Sun, J.*, Rapid detection of plasmid-mediated high-level tigecycline resistance in Escherichia coli and Acinetobacter spp. J Antimicrob Chemother. 2020;75, 1479-1483.

  4. Cui, C.Y., Chen, C., Liu, B.T., He, Q., Wu, X.T., Sun, R.Y., Zhang, Y., Cui, Z.H., Guo, W.Y., Jia, Q.L., Li, C., Kreiswirth, B.N., Liao, X.P., Chen, L., Liu, Y.H., Sun, J.*. Co-occurrence of Plasmid-Mediated Tigecycline and Carbapenem Resistance in Acinetobacter spp. from Waterfowls and Their Neighboring Environment. Antimicrob Agents Chemother. 2020; 64(5),e02502-19.

  5. Sun, J.#, Chen, C.#, Cui, C.Y., Zhang, Y., Liu, X., Cui, Z.H., Ma, X.Y., Feng, Y., Fang, L.X., Lian, X.L., Zhang, R.M., Tang, Y.Z., Zhang, K.X., Liu, H.M., Zhuang, Z.H., Zhou, S.D., Lv, J.N., Du, H., Huang, B., Yu, F.Y., Mathema, B., Kreiswirth, B.N., Liao, X.P.*, Chen, L.*, Liu, Y.H.*,Plasmid-encoded tet(X) genes that confer highlevel tigecycline resistance in Escherichia coli.Nature Microbiology,2019;4:1457-1464.

  6. Chen, C., Cui, C.Y., Zhang, Y., He, Q., Wu, X.T., Li, G., Liao, X.P., Kreiswirth, B.N., Liu, Y.H., Chen, L., Sun, J.*,. Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China. Emerg Microbes Infect. 2019; 8, 1219-1222.

  7. Sun, J.#, Zhang, H.#, Liu, Y.H.*, Feng, Y.*,. Towards Understanding MCR-like Colistin Resistance. Trends Microbiol. 2018; 26, 794-808.

  8. Sun, J#.; Li, X. P#.; Fang, L. X.; Sun, R. Y.; He, Y. Z.; Lin, J.; Liao, X. P.; Feng, Y*.; Liu, Y. H*, Co-occurence of mcr-1 in the chromosome and IncHI2 plasmid: persistence of colistin resistance in escherichia coli. International Journal of Antimicrobial Agents, 2018 6,22. pii: S0924-8579(18)30010-4.

  9. Sun, J#., Xu, Y.#, Gao, R #, Lin, J.#, Wei, W., Srinivas, S., Li, D., Yang, R.S., Li, X.P., Liao, X.P., Liu, Y.H.*, Feng, Y.*, Deciphering MCR-2 Colistin Resistance. mBio. 2017; 8, 3:e00625-17.

  10.  Sun, J#, Yang, R.S. #, Zhang, Q., Feng, Y., Fang, L.X., Xia, J., Li, L., Lv, X.Y., Duan, J.H., Liao, X.P.*, Liu, Y.H.*, 2016. Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli. Nat Microbiol 1, 16176.

     

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